brain

Catalan researchers develop gene therapy reversing memory loss in mice with early-stage Alzheimer's

April 23, 2014 06:57 PM | ACN

Scientists at the Universitat Autònoma de Barcelona (UAB) have found that an alteration of a neuronal gene program plays an essential role in the first stages of Alzheimer's disease and have developed a gene therapy which is effective on mice. The Catalan study occupies the front page of 'The Journal of Neuroscience'. Researchers have identified a new mechanism that regulates the expression of genes in the brain which are essential for the function of neuronal circuits involved in learning and memory. According to the new study, which was carried out by Dr. Carlos Saura's group at the UAB's Institute of Neurosciences (Institut de Neurociències), the alteration of a gene program mediating neuronal transmission and survival may underlie memory loss at early pathological stages of Alzheimer's disease (AD).

Scientific study directed by Dr. Joan Massagué uncovers the mechanisms of brain metastasis

February 28, 2014 05:10 PM | ACN

A scientific research conducted at the Memorial Sloan-Kettering Centre in New-York, and directed by Catalan Oncologist Joan Massagué has shed light on the biological mechanisms used by cancer cells to metastasise in the brain. The study, published in the 27th of February issue of ‘Cell’ magazine, reveals that cancer cells which manage to form new tumours in the brain, do so by attaching themselves to capillaries and secreting special proteins to overpower the brain’s defence mechanisms. According to Dr. Massagué - recently appointed Scientific Director of the Sloan Kettering Institute for leading the way in research on metastasis and cell-growth - the study could be instrumental in preventing and treating Multiple-Organ- Metastasis.