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Investigation finds that genetic mutations could be detected decades before tumor appears

A new computational method allows the detection, within just a few hours, of the genetic alterations responsible for the formation and progression of cancer tumours. This new method manages to accurately identify almost all types of genetic changes of cancer cells in a simple, quick and precise way. It is also able to identify large-scale chromosome rearrangements, which had been difficult to be detect until this breakthrough. The new method, called SMUFIN, has been developed by the Barcelona Supercomputing Centre and the ICREA (Catalan Institution of Research and Advanced Studies), in collaboration with research groups from Barcelona, Oviedo and Heidelberg. This progress has been published by the prestigious journal 'Nature Biotechnology' and represents a significant step forward towards the personalised treatment of cancer and other illnesses.

Researchers from Barcelona’s Hospital Clínic and the University of Oviedo (Asturias) have sequenced Chronic Lymphocytic Leukaemia’s entire genome for the first time. Mutations in four genes have been identified as one of the illness triggers. The study was published last Sunday in the prestigious journal ‘Nature’.